Reliable, high throughput KV7 assays are important because KV7 ion channels play a key role in regulating neuronal excitability, which is closely linked to both pain signalling and seizure activity.

Kv7 ion channels are highly relevant to epilepsy because they are voltage gated potassium ion channels that help regulate neuronal excitability and suppress excessive electrical firing in the brain.

Kv7 channels are a family of voltage gated potassium ion channels that play a key role in controlling cellular excitability.

CiPA logoThe International Council on Harmonization (ICH) S7B and E14 regulatory guidelines were introduced in 2005 to evaluate the proarrhythmic liability of new drugs.

Epilepsy is a chronic neurological disorder characterised by recurrent, unprovoked seizures caused by abnormal electrical activity in the brain. Seizures can vary widely in severity and presentation, ranging from brief lapses in awareness to widespread convulsions.

Ion channels are large multi-subunit transmembrane proteins that control the flow of charged ions across the cell membrane, leading to changes in cellular excitability and intracellular signalling.

Transient receptor potential (TRP) channels are a family of ion channels distantly related to the voltage-gated superfamilies

The voltage-gated potassium channel family is composed of forty members and they are separated into twelve classes Kv1 to Kv12

The voltage-gated sodium channel family is composed of nine pore-forming members, which are named Nav1.1 to Nav1.9 and encoded by genes referred to as SCN1A to SCN11A