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A clinically translatable hiPSC cardiomyocyte model to predict QTc and QRS cardiac risk: Presenting Metrion's VOLTA assay

Presented at the SPS meeting in September 2024, Dr Steve Jenkinson presents Metrion’s human induced pluripotent stem cell (hiPSC)-derived cardiomyocyte assay, an advanced tool, providing key advantages, for early cardiac derisking in drug discovery.

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The state of the art in secondary pharmacology and its impact on the safety of new medicines

Jenkinson, Steve Advanced In Vitro Screening of New Drugs for Proarrhythmic Activity, Genetic Engineering News. 2024 44:5, 48-50

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Assessing the variability of hERG data generated using a mock action potential waveform and automated patch clamp platforms

The HESI Cardiac Safety Committee present results from an international ion channel research study that assessed the variability of hERG data generated using automated patch clamp platforms (QPatch 48, Qube 384 and the SyncroPatch 384i) across four different labs.

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Using high-throughput automated patch clamp electrophysiology to identify novel TREK-1 modulators in an animal venom library

We developed a high-throughput, electrophysiological assay of TREK-1 function to identify novel modulators. The assay was optimized to identify both activators and inhibitors, providing comprehensive mechanistic data for high value, limited supply screening libraries, such as the venom fraction library used in this study (Targeted Venom Discovery Array, T-VDA, Venomtech, UK).

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Specialist neuroscience services brochure

Highly specialised and tailored neuronal assays for pharmacological screening.

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Cardiac safety screening services brochure

Reliably evaluate the proarrhythmic and cardiotoxic liabilities of your compounds.

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Ion channel and HTS services

Specialist ion channel screening to accelerate early-stage screening and lead optimisation.

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Development and validation of a dual modality TREK-1 screening assay on the automated patch clamp Qube 384 platform

We report the development and optimisation of a TREK-1 functional assay using the Qube 384, an automated patch clamp platform capable of supporting high-throughput screening. The assay was optimized to identify both activators and inhibitors on the same plate, providing key mechanistic data for high value, limited supply screening libraries such as venom fractions used in this study (Targeted Venom Discovery Array, TVDA, Venomtech, UK).

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Scientifica PatchScope Pro: an integrated calcium-imaging and patch-clamp system suitable for selecting specific subsets of neurons for electrophysiology recordings

Scientifica’s PatchScope Pro is an integrated electrophysiology rig incorporating an inverted phase-contrast fluorescence microscope, motorised XY stage and PatchStar micromanipulators, suitable for patch-clamp recording.

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Fluorescence-based drug repurposing screen of the potassium channel, KV3.1 with V434L mutation

KV3.1 is a voltage-gated potassium channel encoded by the KCNC1 gene. Mutations in the KV3.1 protein can manifest as a variety of neurological disorders including myoclonic epilepsy and ataxia due to K+ channel mutation (MEAK), developmental epileptic encephalopathy (DEE), or hypotonia.

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