NS5806, widely used as a Kv4-selective activator, also activates TREK-1 and TREK-2 potassium channels.
Cummins, T.R.; Rush, A.M.; Estacion, M.; Dib-Hajj, S.D.; Waxman, S.G. Nature Protocols. 2009, 4, 1103-12 https://pubmed.ncbi.nlm.nih.gov/19617882/
NS5806, widely used as a Kv4-selective activator, also activates TREK-1 and TREK-2 potassium channels.
Nature Communications paper ‘The nucleobase guanine at the 3′-terminus of oligonucleotide RGLS4326 drives off-target AMPAR inhibition and CNS toxicity'