Using Qube 384, we profiled a panel of NaV inhibitors across species, providing valuable translational insight early in analgesic drug discovery.
E. L. Veale1, P. M. Matthews, A. M. Rush2, E. B. Stevens2, A. Mathie1,3
1Medway School of Pharmacy, University of Kent and University of Greenwich, Chatham Maritime, UK
2Metrion Biosciences, Cambridge, UK
3Schoolof Life Sciences, University of Westminster, London, UK
Pharmacology Research & Perspectives
https://doi.org/10.1002/prp2.70264
Using Qube 384, we profiled a panel of NaV inhibitors across species, providing valuable translational insight early in analgesic drug discovery.
We explore hNav1.9's unique fast and slow inactivation properties using Qube 384 and QPatch 48 platforms, helping to build more predictive screening assays for state-dependent inhibitors.