NS5806, widely used as a Kv4-selective activator, also activates TREK-1 and TREK-2 potassium channels.
Tomašić, T.; Hartzoulakis. B.; Zidar. N.; Chan, F.; Kirby R.W.; Madge, D.J.; Peigneur, S.; Tytgat, J.; Kikelj, D. Journal of Chemical Information and Modelling. 2013, 53 (12), 3223-32
NS5806, widely used as a Kv4-selective activator, also activates TREK-1 and TREK-2 potassium channels.
Nature Communications paper ‘The nucleobase guanine at the 3′-terminus of oligonucleotide RGLS4326 drives off-target AMPAR inhibition and CNS toxicity'