NS5806, widely used as a Kv4-selective activator, also activates TREK-1 and TREK-2 potassium channels.
Gary Stephens 1, Edwards Stevens 2
1School of Pharmacy, University of Reading, Reading, UK
2Metrion Biosciences Ltd., Cambridge, UK
(2024) Springer Nature
10.1007/978-3-031-52197-3
NS5806, widely used as a Kv4-selective activator, also activates TREK-1 and TREK-2 potassium channels.
Nature Communications paper ‘The nucleobase guanine at the 3′-terminus of oligonucleotide RGLS4326 drives off-target AMPAR inhibition and CNS toxicity'