NS5806, widely used as a Kv4-selective activator, also activates TREK-1 and TREK-2 potassium channels.
Ford J.; Milnes J.; Wettwer E.; Christ T.; Rogers M.; Sutton K.; Madge D.; Virag L.; Jost N.; Horvath Z.; Matschke K.; Varro A.; Ravens, U. Journal of Cardiovascular Pharmacology. 2013, 61 (5), 408-415
NS5806, widely used as a Kv4-selective activator, also activates TREK-1 and TREK-2 potassium channels.
Nature Communications paper ‘The nucleobase guanine at the 3′-terminus of oligonucleotide RGLS4326 drives off-target AMPAR inhibition and CNS toxicity'