NS5806, widely used as a Kv4-selective activator, also activates TREK-1 and TREK-2 potassium channels.
Rush, A.M.; Dib-Hajj, S.D.; Liu, S.; Cummins T.R.; Black, J.A.; Waxman, S.G. Proceedings of the National Academy of Science USA. 2006, 103, 8245-50
NS5806, widely used as a Kv4-selective activator, also activates TREK-1 and TREK-2 potassium channels.
Nature Communications paper ‘The nucleobase guanine at the 3′-terminus of oligonucleotide RGLS4326 drives off-target AMPAR inhibition and CNS toxicity'