NS5806, widely used as a Kv4-selective activator, also activates TREK-1 and TREK-2 potassium channels.
Rogers, M.; Tang L.; Madge, D.; Stevens E. Seminars in cell and developmental biology. 2006, 17 (5), 571-581
NS5806, widely used as a Kv4-selective activator, also activates TREK-1 and TREK-2 potassium channels.
Nature Communications paper ‘The nucleobase guanine at the 3′-terminus of oligonucleotide RGLS4326 drives off-target AMPAR inhibition and CNS toxicity'