NS5806, widely used as a Kv4-selective activator, also activates TREK-1 and TREK-2 potassium channels.
Hodnik, Ž.; Tomašić, T.; Mašič L.P.; Chan, F.; Kirby, R.W.; Madge D.J.; Kikelj, D. European Journal of Medicinal Chemistry. 2013, 70, 154-64
NS5806, widely used as a Kv4-selective activator, also activates TREK-1 and TREK-2 potassium channels.
Nature Communications paper ‘The nucleobase guanine at the 3′-terminus of oligonucleotide RGLS4326 drives off-target AMPAR inhibition and CNS toxicity'