NS5806, widely used as a Kv4-selective activator, also activates TREK-1 and TREK-2 potassium channels.
Stevens, E.B.; Stephens, G.J. British Journal of Pharmacology. 2018, 175 (12), 2133-2137
NS5806, widely used as a Kv4-selective activator, also activates TREK-1 and TREK-2 potassium channels.
Nature Communications paper ‘The nucleobase guanine at the 3′-terminus of oligonucleotide RGLS4326 drives off-target AMPAR inhibition and CNS toxicity'