Utility of human iPSC-derived CMs for preclinical safety assays and disease modelling

Authors

Sarah Williams, PhD, Senior Scientist, Metrion Biosciences

Overview

This talk was presented by Dr Sarah Williams at the Axol Metrion Interactive Stem Cell Forum held in May 2018. This project received funding from the Eurostars-2 joint program with co-funding from the European Union Horizon 2020 Research and Innovation Program.

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Background

Applications of human iPSC derived cardiomyocytes
Human induced pluripotent stem cell derived cardiomyocytes (iPSC CM) can be differentiated from healthy or diseased donors.

Many applications of iPSC CM including:

  • Study of channelopathies e.g. long QT syndromes
  • Development of patient specific pharmacology
  • Stem cell therapies
  • Drug screening and preclinical safety assessment

To successfully utilise iPSC CM as a model system they need thorough functional characterisation.

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