Define clinical exposure associated with QTc liability

Data Card

Define clinical exposure associated with QTc liabilityEarly cardiac derisking: A clinically translatable hiPSC cardiomyocyte assay

Achieve action potential recordings from intrinsically paced hiPSC-CMs with Metrion’s clinically predictive hiPSC cardiomyocyte assay.

  • Simultaneous high-resolution measurement across 96 well plate at 10,000 Hz
  • Recordings using voltage-sensitive dye equivalent in quality to patch clamp
  • Multiple endpoints evaluated (APD20/50/90, rise time, beat rate, triangulation)
  • Measurement of acute (30min) and chronic (24h/48h) effects
  • Predicts clinical exposure associated with 10ms QTc prolongation
  • Defines exposure associated with QRS probability
  • Highlights unknown acute/chronic toxicity

Read more about our hiPSC cardiomyocyte assay.

Contact us for a quote or discussion



Recommended Publications
Latest Publications
Pharmacological assessment of hNav1.9 and rNav1.9 using Qube automated patch clamp

Using Qube 384, we profiled a panel of NaV inhibitors across species, providing valuable translational insight early in analgesic drug discovery.

Biophysical assessment of hNav1.9 using QPatch and Qube automated patch clamp

We explore hNav1.9's unique fast and slow inactivation properties using Qube 384 and QPatch 48 platforms, helping to build more predictive screening assays for state-dependent inhibitors.

View All
Metrion is a contract research organisation (CRO) specialising in high-quality preclinical drug discovery services.
magnifier
linkedin facebook pinterest youtube rss twitter instagram facebook-blank rss-blank linkedin-blank pinterest youtube twitter instagram