Define clinical exposure associated with QTc liability

Data Card

Define clinical exposure associated with QTc liabilityEarly cardiac derisking: A clinically translatable hiPSC cardiomyocyte assay

Achieve action potential recordings from intrinsically paced hiPSC-CMs with Metrion’s clinically predictive hiPSC cardiomyocyte assay.

  • Simultaneous high-resolution measurement across 96 well plate at 10,000 Hz
  • Recordings using voltage-sensitive dye equivalent in quality to patch clamp
  • Multiple endpoints evaluated (APD20/50/90, rise time, beat rate, triangulation)
  • Measurement of acute (30min) and chronic (24h/48h) effects
  • Predicts clinical exposure associated with 10ms QTc prolongation
  • Defines exposure associated with QRS probability
  • Highlights unknown acute/chronic toxicity

Read more about our hiPSC cardiomyocyte assay.

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Using high-throughput automated patch clamp electrophysiology to identify novel TREK-1 modulators in an animal venom library

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Metrion Biosciences is a contract research organisation (CRO) specialising in high-quality preclinical drug discovery services.
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