Define clinical exposure associated with QTc liability

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Early cardiac derisking: A clinically translatable hiPSC cardiomyocyte assay

Achieve action potential recordings from intrinsically paced hiPSC-CMs with Metrion’s clinically predictive hiPSC cardiomyocyte assay.

Simultaneous high-resolution measurement across 96 well plate at 10,000 Hz
Recordings using voltage-sensitive dye equivalent in quality to patch clamp
Multiple endpoints evaluated (APD20/50/90, rise time, beat rate, triangulation)
Measurement of acute (30min) and chronic (24h/48h) effects
Predicts clinical exposure associated with 10ms QTc prolongation
Defines exposure associated with QRS probability
Highlights unknown acute/chronic toxicity

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