Define clinical exposure associated with QTc liability

Data Card

Define clinical exposure associated with QTc liabilityEarly cardiac derisking: A clinically translatable hiPSC cardiomyocyte assay

Achieve action potential recordings from intrinsically paced hiPSC-CMs with Metrion’s clinically predictive hiPSC cardiomyocyte assay.

  • Simultaneous high-resolution measurement across 96 well plate at 10,000 Hz
  • Recordings using voltage-sensitive dye equivalent in quality to patch clamp
  • Multiple endpoints evaluated (APD20/50/90, rise time, beat rate, triangulation)
  • Measurement of acute (30min) and chronic (24h/48h) effects
  • Predicts clinical exposure associated with 10ms QTc prolongation
  • Defines exposure associated with QRS probability
  • Highlights unknown acute/chronic toxicity

Read more about our hiPSC cardiomyocyte assay.

Contact us for a quote or discussion



Recommended Publications
Latest Publications
Development of Automated Electrophysiology Assays for the Characterisation of Inhibitors Against Human HCN Ion Channels

We demonstrate the generation and validation of a stable CHO-hHCN2 cell line used as a cellular tool in the successful development of hHCN2 automated electrophysiology screening assays.

Seal enhancers on the Qube 384: An alternative to F

Metrion and Sophion collaborated to determine whether other insoluble salts can act as seal enhancers, or whether this property is unique to CaF2.

View All
Review of Academic Ion Channels Drug Discovery Workshop 2025
Development of Automated Electrophysiology Assays for the Characterisation of Inhibitors Against Human HCN Ion Channels
View All
Metrion Biosciences is a contract research organisation (CRO) specialising in high-quality preclinical drug discovery services.
Copyright © 2024 Metrion. All rights reserved | Privacy notice | Registered as a company in England and Wales: 09669815 | VAT: GB 219828479
magnifier
linkedin facebook pinterest youtube rss twitter instagram facebook-blank rss-blank linkedin-blank pinterest youtube twitter instagram