hiPSC-derived Cardiomyocyte Screening

Successfully detect between compounds with low, medium and high proarrhythmic risk profiles

Evaluate the effect of compounds on action potentials recorded from hiPSC-derived cardiomyocytes using conventional manual patch clamp methodology.

Spontaneous or evoked action potentials can be recorded and used to determine the effect of compounds on a range of action potential parameters. The recordings are stable for >30 minutes, which allows the cumulative application of multiple concentrations of each compound.

The manual patch clamp assay generates high fidelity recordings that allow the detection of even subtle changes to the action potential waveform. This helps to successfully discern between compounds with low, medium and high proarrhythmic risk profiles. For example, the figures below show mean data generated using 50 nM dofetilide, which reveals a significant prolongation of all measured APD values.

Figure 1. hiPSC-derived cardiomyocyte action potential screening.

Figure 2. Drug effects on hiPSC-derived cardiomyocyte responses.

Figure 3. Changes in hiPSC-derived cardiomyocyte beat stability.

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Cardiac Safety Screening Resource Library

Assessing the Variability of hERG Data Generated Using a Mock Action Potential Waveform and Automated Patch Clamp Platforms

The HESI Cardiac Safety Committee present results from an international ion channel research study that assessed the variability of hERG data generated using automated patch clamp platforms (QPatch 48, Qube 384 and the SyncroPatch 384i) across four different labs.

Cardiac Safety Screening Services

Reliably evaluate the proarrhythmic and cardiotoxic liabilities of your compounds.

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Metrion Biosciences

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If you have any questions or would like to discuss your specific assay requirements, we will put you directly in touch with a member of our scientific team. Contact us today to discover more.

Metrion Biosciences is a contract research organisation (CRO) specialising in high-quality preclinical drug discovery services.

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hiPSC-derived Cardiomyocyte Screening

Successfully detect between compounds with low, medium and high proarrhythmic risk profiles

Let's Work Together

Let’s work together

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hiPSC-derived Cardiomyocyte Screening

Successfully detect between compounds with low, medium and high proarrhythmic risk profiles

Let's Work Together

Let’s work together

Let's Work Together

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About Metrion

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