Specialist ion channel screening to accelerate early-stage screening and lead optimisation

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Fully customised ion channel assays

We understand the importance of robust, reliable assays in enabling you to make timely, well-informed decisions. Using innovative solutions tailored to your specific target, we focus on rapid delivery of high-quality data to accelerate your early-stage compound screening and lead optimisation programmes.

Our specialist team of ion channel scientists are experts in their field. With over 250 years’ collective ion channel drug discovery experience, we specialise in developing, optimising and validating high-quality ion channel screening services using a range of electrophysiology and fluorescence-based platforms.

We fully customise ion channel assays at different stages of the screening cascade, from high-throughput screening (HTS) and structure-activity relationship (SAR) studies, through to specialised biophysical and mechanism-of-action studies for lead compounds.
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Figure 1. Example recording of hASIC1a inward current recorded on the Sophion Qube automated electrophysiology platform. Cells are held at -60 mV with ASIC1a activated by the addition of extracellular solution buffered to pH 6.3 (black traces). The effect of inhibitor, diminazene, at 100 nM and 30 µM on the inward current is displayed in the blue and red traces, respectively.
Figure 2. Diminazene concentration-response curve displaying an IC50 of 1.13 µM (pIC50 = 5.95).
Figure 3. The pIC50 values of the reference compound, diminazene, against ASIC1a included in the Qube experiments when supporting Medicinal Chemistry Hit-to-Lead activities.

Reliable data you can trust

Our expertise in electrophysiology and fluorescence-based assays stands us apart, guaranteeing robust and reliable data.

We strive to exceed our clients’ expectations and to build long-term partnerships based on trust:
High quality, cost-efficient compound screening.
Rapid reporting and data interpretation by experienced ion channel experts.
Tailored, target-focussed assay development, including complex assays.
In-house generation and validation of novel ion channel cell lines.
Detailed characterisation of lead compounds in a range of complementary assays.
Translational services including confirmation of efficacy.
Access to commercially available compound libraries (Assay.Works and Enamine) with freedom to operate.
Ion Channel Screening Resource Library
Using high-throughput automated patch clamp electrophysiology to identify novel TREK-1 modulators in an animal venom library

We developed a high-throughput, electrophysiological assay of TREK-1 function to identify novel modulators. The assay was optimized to identify both activators and inhibitors, providing comprehensive mechanistic data for high value, limited supply screening libraries, such as the venom fraction library used in this study (Targeted Venom Discovery Array, T-VDA, Venomtech, UK).

Ion Channel and HTS Services

Specialist ion channel screening to accelerate early-stage screening and lead optimisation.

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Metrion Biosciences

Let’s work together

If you have any questions or would like to discuss your specific assay requirements, we will put you directly in touch with a member of our scientific team. Contact us today to discover more.
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Metrion Biosciences is a contract research organisation (CRO) specialising in high-quality preclinical drug discovery services.
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