The high-throughput screening of vast numbers of compounds is pivotal to the drug discovery process. It is often an expensive, timely, process which can return false positive results. What sets us apart is our specific high-throughput screening knowledge and experience across multiple ion channel targets.
By working with our ion channel high-throughput screening specialists you will have access to a dedicated and highly experienced team, with experience including high-throughput ion channel screening to support HTS campaigns, hit finding, hit-to-lead, lead optimisation and follow-up selectivity profiling. Custom cell line generation, assay development and optimisation is also provided in-house.
Once we have run your project, we will interpret the data, communicate the results and support your decision making to best inform your screening strategy.
Our complementary phenotypic and translational assays enable further detailed characterisation of your lead compounds. Read about our small molecule library and modular screening decks to suit your project and budget.
We developed a high-throughput, electrophysiological assay of TREK-1 function to identify novel modulators. The assay was optimized to identify both activators and inhibitors, providing comprehensive mechanistic data for high value, limited supply screening libraries, such as the venom fraction library used in this study (Targeted Venom Discovery Array, T-VDA, Venomtech, UK).
Specialist ion channel screening to accelerate early-stage screening and lead optimisation.