High-quality, cost-effective and rapid-turnaround, GLP testing against hERG

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Metrion ensures customers receive accurate and reliable data without compromising on quality

Metrion Biosciences is a leading provider of high-quality GLP (Good Laboratory Practice) hERG testing services, designed to meet the stringent needs of pharmaceutical and biotech companies involved in drug discovery. With a strong focus on delivering cost-effective solutions, Metrion ensures customers receive accurate and reliable data without compromising on quality, all within a remarkably quick turnaround time.

The hERG (human Ether-à-go-go-Related Gene) assay is a critical component in the early stages of drug discovery, and GLP hERG testing is vitally important for the Investigational New Drug (IND) process.
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Robust, reproducible, and compliant data

Metrion has invested in state-of-the-art electrophysiology platforms and employs highly trained scientists to ensure the highest data quality.

The rigorous standards that Metrion adheres to guarantee that the data generated is robust, reproducible, and compliant with regulatory guidance, making it suitable for submission to regulatory authorities worldwide.
Figure 1. A. Graph showing the peak hERG tail current plotted against time for a representative cell treated with 1 and 10 μM ondansetron followed by 1 μM E-4031. The inset figure shows representative current traces in 0.1% DMSO, ondansetron and E-4031. B. Graph showing the mean ± SD inhibition data (purple symbols), as well as individual inhibition values (grey symbols), plotted against concentration. The data were fitted with a Hill equation to yield the half-maximal inhibition concentration (IC50) and the 95% confidence bands (red dashed lines).

Rapid turnaround of GLP hERG testing

One of the key strengths of Metrion’s GLP hERG testing service is the rapid turnaround time. In the fast-paced world of drug discovery, delays in safety testing can slow down the entire discovery process, potentially leading to increased costs and lost opportunities. We understand this urgency and have streamlined processes to deliver GLP hERG testing results in a timeframe that supports the accelerated pace of modern drug discovery.

This speed does not come at the expense of quality; every assay is meticulously conducted, and data is rigorously analysed to ensure it meets the highest standards.

Cost efficient GLP hERG testing

Cost is another critical consideration for companies outsourcing their GLP hERG testing needs. Metrion offers a highly competitive pricing structure, making it possible for organizations of all sizes to access premium GLP hERG testing services without straining their budgets. We provide these services at competitive rates without sacrificing the quality of the data.

Customer-centric approach

Each customer receives personalized service tailored to their specific needs. Whether a single study or a series of testing over the course of a project, Metrion is equipped to provide flexible solutions that fit within the customer’s timelines and budget.

This adaptability is particularly valuable for smaller biotech firms and academic institutions, which may have more limited resources but still require high-quality data to advance their drug discovery programs.

We are committed to maintaining the highest standards of scientific excellence while ensuring our services remain accessible and affordable. By choosing Metrion for GLP hERG testing, customers can be confident that they are receiving reliable, regulatory-compliant data that will support their decision-making processes and help bring safer, more effective drugs to market faster.
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Cardiac Safety Screening Resource library
A clinically translatable hiPSC cardiomyocyte model to predict QTc and QRS cardiac risk: Presenting Metrion's VOLTA assay

Presented at the SPS meeting in September 2024, Dr Steve Jenkinson presents Metrion’s human induced pluripotent stem cell (hiPSC)-derived cardiomyocyte assay, an advanced tool, providing key advantages, for early cardiac derisking in drug discovery.

The state of the art in secondary pharmacology and its impact on the safety of new medicines

Jenkinson, Steve Advanced In Vitro Screening of New Drugs for Proarrhythmic Activity, Genetic Engineering News. 2024 44:5, 48-50

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Metrion Biosciences

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If you have any questions or would like to discuss your specific assay requirements, we will put you directly in touch with a member of our scientific team. Contact us today to discover more.
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Metrion Biosciences is a contract research organisation (CRO) specialising in high-quality preclinical drug discovery services.
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