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Development and validation of a Qube automated patch clamp hERG assay at physiological temperatures

The development of Automated Patch Clamp (APC) technology over the last 20 years has
transformed the research and development process for identifying novel drugs for ion channel targets.

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Metrion Biosciences cardiac safety services overview

Here we share a short video introducing Metrion’s extensive suite of cardiac safety screening services. To learn more, or to request a quote, please email info@metrionbiosciences.com

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What are ion channels?

Ion channels are large multi-subunit transmembrane proteins that control the flow of charged ions across the cell membrane, leading to changes in cellular excitability and intracellular signalling.

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Gain-of-function mutations in Nav1.6 and epileptic seizures

Watch on demand the Metrion Biosciences webinar presented by Manoj K. Patel, Ph.D, Associate Professor at the University of Virginia where he speaks about “Gain-of-function mutations in Nav1.6 and epileptic seizures“.

The webinar took place on Thursday 29th November 2022 at 16:00 EDT.

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Development of ASIC1a ligand-gated ion channel drug screening assays across multiple automated patch clamp platforms

Ridley, J., Manyweathers, S., Tang, R., Goetze, T., Becker, N., Kirby, R., Obergrussberger, A., & Rogers, M. (2022). Development of ASIC1a ligand-gated ion channel drug screening assays across multiple automated patch clamp platforms. Frontiers in Molecular Neuroscience. Frontiers in Molecular Neuroscience, 2022.https://www.frontiersin.org/journals/molecular-neuroscience/articles/10.3389/fnmol.2022.982689/full

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Metrion Biosciences – Laboratory tour

Metrion Biosciences is a specialist ion channel contract research organisation providing drug discovery services to pharmaceutical and bioscience customers worldwide. Discover more about our capabilities and facilities in this short introductory video.

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What are Transient Receptor Potential ion channels?

Transient receptor potential (TRP) channels are a family of ion channels distantly related to the voltage-gated superfamilies

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What are voltage-gated potassium ion channels?

The voltage-gated potassium channel family is composed of forty members and they are separated into twelve classes Kv1 to Kv12

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What are voltage-gated sodium channels?

The voltage-gated sodium channel family is composed of nine pore-forming members, which are named Nav1.1 to Nav1.9 and encoded by genes referred to as SCN1A to SCN11A

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Metrion Webinar – Dr. Kris Kahlig

Dr. Kris Kahlig is the Head of Biology at Praxis Precision Medicines Inc. a clinical stage biopharmaceutical company translating genetic insights into the development of therapies for patients affected by CNS disorders. Kris presented at the Metrion Webinar series on “Using Dynamic Action Potential Clamp Modelling of Nav1.2 Variants to Support the Prediction of Clinical Phenotype in DEE”.

The webinar took place on Thursday 5th May 2022 at 16:00 BST.

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Metrion Biosciences is a contract research organisation (CRO) specialising in high-quality preclinical drug discovery services.
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