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Rescue of defective CFTR (dF508) is enhanced by targeting the ubiquitin proteasomal system

The dF508 mutation represents the most common cause underlying cystic fibrosis. The resultant misfolding of the nascent cystic fibrosis transmembrane regulator (CFTR) protein and its subsequent proteasomal degradation lead to a deficiency in functional CFTR channels and Cl- efflux at the apical cell membrane in ducts throughout the body (Veit et al. 2016).

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Metrion Biosciences High Throughput Screening Services

Here we share a short video introducing Metrion’s expanded high throughput screening capabilities. To learn more, or to request a quote, please email info@metrionbiosciences.com

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Development and validation of a Qube automated patch clamp hERG assay at physiological temperatures

The development of Automated Patch Clamp (APC) technology over the last 20 years has
transformed the research and development process for identifying novel drugs for ion channel targets.

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Metrion Biosciences cardiac safety services overview

Here we share a short video introducing Metrion’s extensive suite of cardiac safety screening services. To learn more, or to request a quote, please email info@metrionbiosciences.com

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What are ion channels?

Ion channels are large multi-subunit transmembrane proteins that control the flow of charged ions across the cell membrane, leading to changes in cellular excitability and intracellular signalling.

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Gain-of-function mutations in Nav1.6 and epileptic seizures

Watch on demand the Metrion Biosciences webinar presented by Manoj K. Patel, Ph.D, Associate Professor at the University of Virginia where he speaks about “Gain-of-function mutations in Nav1.6 and epileptic seizures“.

The webinar took place on Thursday 29th November 2022 at 16:00 EDT.

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Development of ASIC1a ligand-gated ion channel drug screening assays across multiple automated patch clamp platforms

Ridley, J., Manyweathers, S., Tang, R., Goetze, T., Becker, N., Kirby, R., Obergrussberger, A., & Rogers, M. (2022). Development of ASIC1a ligand-gated ion channel drug screening assays across multiple automated patch clamp platforms. Frontiers in Molecular Neuroscience. Frontiers in Molecular Neuroscience, 2022.https://www.frontiersin.org/journals/molecular-neuroscience/articles/10.3389/fnmol.2022.982689/full

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Metrion Biosciences – Laboratory tour

Metrion Biosciences is a specialist ion channel contract research organisation providing drug discovery services to pharmaceutical and bioscience customers worldwide. Discover more about our capabilities and facilities in this short introductory video.

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What are Transient Receptor Potential ion channels?

Transient receptor potential (TRP) channels are a family of ion channels distantly related to the voltage-gated superfamilies

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What are voltage-gated potassium ion channels?

The voltage-gated potassium channel family is composed of forty members and they are separated into twelve classes Kv1 to Kv12

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Metrion Biosciences is a contract research organisation (CRO) specialising in high-quality preclinical drug discovery services.
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