Modulation of voltage-gated calcium channels in disease

Authors

Professor Gary Stephens

Overview

Presentation from the Metrion Biosciences’ external speaker series, Professor Gary Stephens, University of Reading, 28th November 2016.

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Background

Professor Gary Stephens gave his perspective on his research into calcium channel modulation, cannabinoid-derived anti-epileptic agents; plus biologics and SUMOylation in the field of ion channel modulation as part of Metrion Biosciences External Speaker Series.

Modulation of voltage gated calcium channels in disease slide 7
Modulation of voltage-gated calcium channels in disease – Slide 7
Modulation of voltage gated calcium channels in disease slide 22
Modulation of voltage-gated calcium channels in disease – Slide 22

Extract from our Interview with Professor Gary Stephens

Calcium channels and synaptic transmission are major components of your research career. What inspired you to focus on these areas and what is the basis of your continued interest?

As a post-doctoral worker with Wyeth Research I was bitten by the ion channel electrophysiology bug. Back then (in the early 90’s) I initially worked on cloned potassium channels which were then not widely accessible, but were made available to Wyeth via an academic collaboration. I wanted to move towards ion channel modulation and subsequently became the first post-doctoral researcher in Annette Dolphin’s group (then based at the Royal Free Hospital site of University College London’s Pharmacology Department) to perform electrophysiological work on cloned channels.

Gary gave the first presentation in Metrion Biosciences External Speaker Series in November 2016, his interview can be found in our ConnectIONS blog article here.

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